Brooksville, FL Brooksville is a city in and the county seat of Hernando County, Florida, United States. As of the 2010 census, it had a population of 7,719, up from 7,264 at the 2000 census. It is part of the Tampa-St. Petersburg-Clearwater, Florida Metropolitan Statistical Area. Brooksville, previously Pierceville, took on its present name in 1856, to honor and show support for Preston Brooks, a pro-slavery congressman from South Carolina who caned and seriously injured Massachusetts Senator and abolitionist Charles Sumner. Brooksville is home to historic buildings and residences, including the homes of former Florida Governor William Sherman Jennings and football player Jerome Brown.